Cachexia is a multifaceted condition characterized by persistent muscle loss that cannot be completely remedied through standard nutritional support, resulting in a decline in functionality. It can be masked by excess weight, obesity, edema, or the presence of tumor mass. Anorexia, which involves a diminished appetite, is often observed in cancer patients, although its precise prevalence remains unclear.
When cachexia primarily stems from decreased food intake, it is termed cancer-related cachexia and anorexia syndrome (CACS). This condition encompasses muscle wasting, lipolysis, and reduced food consumption, distinguishing it from simple cachexia.
Some researchers suggest that cannabis from Weedsy Canada weed delivery services may enhance appetite and alleviate nausea in cancer patients.
Table of Contents
Key Takeaways:
- THC capsules available at Weedsy Canada could assist cancer patients in eating more and experiencing less sickness, thereby improving their quality of life.
- Studies indicate that cannabis influences brain cells responsible for hunger, which may help address appetite issues in cancer patients and others.
- THC capsules are precise, convenient, discreet, and long-lasting, making them ideal for medical marijuana users who prefer not to smoke.
Cancer Cachexia and Anorexia Syndrome
Cachexia represents a condition signified by considerable weight loss due to the depletion of muscle and fat, commonly observed in patients with severe diseases such as heart failure, HIV/AIDS, COPD, kidney failure, and especially cancer.
This condition is typically associated with anorexia, which involves a reduced appetite leading to a minimum of 5% loss in body weight. Together, they comprise cancer anorexia-cachexia syndrome (CACS).
Hospitalized cancer patients frequently exhibit inadequate dietary intake, with nearly half being malnourished or at risk. Cachexia not only undermines patients’ quality of life but also impedes treatment and can hasten the end of life. Its occurrence sharply increases as death approaches, with cachexia cited as the leading cause of death in over 20% of cases.
Despite its prevalence, CACS often goes unnoticed and untreated in clinical environments due to unclear definitions, diagnostic criteria, classification systems, and approved therapies. Clinicians evaluate a patient’s nutritional status through various measures, including body weight, skin fold thickness, and mid-arm circumference, though body weight is commonly relied upon, typically using inappropriate reference weights.
Treatment
The most straightforward approach to address anorexia is to enhance nutrition, yet evidence supporting its effectiveness remains limited. For cancer patients, nutritional care typically involves:
- Dietary Counseling
- Oral Supplements
- Enteral and Parenteral Nutrition
However, the success of these methods can vary based on the cancer type and stage.
Pharmacological Approaches
Currently, no verified medications exist for treating Cancer Anorexia-Cachexia Syndrome (CACS), though some drugs are used off-label or are under clinical trials. These medications are categorized based on their mechanisms:
- Appetite Stimulants
- Cytokine Modulators
- Anabolic Agents
- Combination Therapies
Additionally, megestrol acetate, a progestin, is utilized separately due to its unclear mechanism of action.
Cannabis in Medicine
The cannabinoid could enhance the quality of life for cancer patients and pave the way for future treatments, providing hope for those suffering from cachexia, a condition that causes appetite loss and malnourishment. It offers relief without intoxicating effects, making it a potential solution for these patients.
Various cannabis formulations with differing effects are available, including inhaled THC for rapid onset and short-lived effects, and orally ingested THC for slower absorption and prolonged effects. Sublingual administration allows for rapid onset and lasts for 2 to 4 hours.
Clinical Trial
A study conducted by researchers from Israel and the United States evaluated how cannabis pills impact CACS in advanced cancer patients. This research significantly influences the treatment of appetite disorders affecting cancer patients, individuals with anorexia, and potentially those with obesity.
Methods
The study involved cannabis capsules containing two types of oil-based compounds. Participants were treated with 10 mg doses twice daily for six months, including 9.5 mg of tetrahydrocannabinol (THC) and 0.5 mg of cannabidiol (CBD).
If participants experienced side effects, the dose was adjusted to 5 mg twice daily (4.75 mg THC and 0.25 mg CBD). At each doctor visit, participants were weighed. The primary goal was for participants to gain at least 10% more weight than their initial weight.
Results
Out of 24 patients who agreed to participate, 17 began treatment with cannabis capsules. However, only 11 continued taking the capsules for over two weeks. By the end of the study, 3 out of 6 patients who completed the treatment achieved the primary goal of gaining at least 10% more weight, while the weight of the other three remained unchanged.
Tumor necrosis factor-α (TNF-α), an inflammation marker, decreased following the treatment. Patients reported improved appetite and mood, alongside reduced pain and fatigue.
Despite facing challenges, this initial study recorded a weight gain of 10% or more in 3 out of 17 patients (17.6%) using daily doses of 5 mg once or twice without significant side effects. These findings support the need for a larger, more controlled study on cannabis capsules in patients with CACS.
Cannabis Capsules
If you enjoy edibles, cannabis flower, or classic pre-rolls, exploring new ways to use cannabis is always thrilling.
THC capsules are among the latest innovations in the cannabis market. These capsules contain a precise dosage of THC, derived from a concentrated cannabis extract and a neutral oil. They function similarly to cannabis tinctures but are in capsule form (also referred to as cannabis oil capsules or THC pills).
Key Components
- Cannabis Extract: This concentrated extract is sourced from the cannabis plant using a chosen extraction method by the manufacturer. THC capsules are rich in THC, and some may contain only CBD or varying CBD/THC ratios.
- Neutral Oil Suspension: Since THC is not soluble in water, it is suspended in an oil for adequate absorption by the body. The most common oils used are medium-chain triglycerides (MCT oils), which aid digestion and absorption.
Benefits
Medical marijuana patients and recreational users can benefit from cannabis capsules. They provide:
- Convenience: Taking a cannabis capsule is as straightforward as any other oral supplement. Simply swallow it with water, without any hassle.
- Precision Dosage: For medical users, precise control over cannabinoid intake is essential for achieving desired effects. With THC capsules, each dose is measured, eliminating guesswork.
- Smoke-Free Option: Many individuals prefer to avoid smoking or vaping for personal preferences or health reasons. THC capsules offer a smoke-free alternative, suitable for those with respiratory issues.
- Longer Effects: Capsules generally provide longer-lasting effects compared to smoking or vaping, making them ideal for sustained relief from symptoms over several hours.
Cannabis Capsules vs. Other Forms of Medicinal Cannabis
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Frequently Asked Questions
What are the different types of capsules?
One significant advantage of cannabis pills/capsules is their versatility – formulators can create various capsule types for consumers to choose from, ensuring you find capsules that suit your personal preference.
- 1:1 Capsules: These capsules provide an equal ratio of THC to CBD in each dose. They can be produced with sativa or indica strains and come in various concentrations such as 5 mg, 20 mg, 50 mg, or 100 mg cannabinoids per capsule.
- 3:1 Capsules: These capsules deliver a ratio of 3 parts CBD to 1 part THC in each dose.
- THC Capsules: These capsules contain THC exclusively, with varying concentrations per capsule, made from different Sativa or Indica strains to produce specific effects.
- CBD Capsules: These contain only CBD, without THC, so they do not induce mind-altering effects. They are designed for individuals seeking the benefits of CBD alone.
How do capsules interact with your body?
- The capsule’s outer shell disintegrates in your digestive tract upon consumption.
- The contents of the capsule are absorbed into the bloodstream.
- THC (and other cannabinoids) are metabolized in the liver.
How long does it take for cannabis capsule effects to kick in?
Typically, THC capsules take about 90 minutes to begin exhibiting effects. The effects can last from 5 to 12 hours, gradually diminishing in intensity. Compared to inhaled cannabis, capsule effects generally endure twice as long on average.
Nevertheless, experiences may vary based on factors such as age, medications, personal cannabis tolerance, and cannabinoid composition. Some users also report different effects depending on specific cannabinoids present, possibly due to the “entourage effect.”
How to mail order marijuana?
To mail order recreational cannabis, locate a trustworthy delivery service online that offers top-quality cannabis products. After selecting your items, choose “order cannabis delivery,” and a delivery driver will safely bring your order. Ensure the service is reputable for a smooth purchase process.
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